Proteomic and metabolomic analyses of the white-rot fungus Phanerochaete chrysosporium exposed to exogenous benzoic acid.
Identifieur interne : 000678 ( Main/Exploration ); précédent : 000677; suivant : 000679Proteomic and metabolomic analyses of the white-rot fungus Phanerochaete chrysosporium exposed to exogenous benzoic acid.
Auteurs : Fumiko Matsuzaki [Japon] ; Motoyuki Shimizu ; Hiroyuki WariishiSource :
- Journal of proteome research [ 1535-3893 ] ; 2008.
Descripteurs français
- KwdFr :
- Acide benzoïque (pharmacologie), Acides aminés (métabolisme), Alcohol oxidoreductases (métabolisme), Aldehyde oxidoreductases (métabolisme), Chromatographie gazeuse-spectrométrie de masse (MeSH), Cycle citrique (effets des médicaments et des substances chimiques), Cytochrome P-450 enzyme system (métabolisme), Glycolyse (effets des médicaments et des substances chimiques), Métabolisme glucidique (effets des médicaments et des substances chimiques), NAD (métabolisme), NADP (métabolisme), Phanerochaete (effets des médicaments et des substances chimiques), Phanerochaete (enzymologie), Phanerochaete (métabolisme), Protéines du choc thermique (métabolisme), Protéines fongiques (analyse), Protéines fongiques (métabolisme), Protéome (analyse), Protéome (métabolisme), Régulation négative (effets des médicaments et des substances chimiques), Régulation positive (effets des médicaments et des substances chimiques), Spectrométrie de masse MALDI (MeSH), Tréhalose (métabolisme), Électrophorèse bidimensionnelle sur gel (MeSH).
- MESH :
- analyse : Protéines fongiques, Protéome.
- effets des médicaments et des substances chimiques : Cycle citrique, Glycolyse, Métabolisme glucidique, Phanerochaete, Régulation négative, Régulation positive.
- enzymologie : Phanerochaete.
- métabolisme : Acides aminés, Alcohol oxidoreductases, Aldehyde oxidoreductases, Cytochrome P-450 enzyme system, NAD, NADP, Phanerochaete, Protéines du choc thermique, Protéines fongiques, Protéome, Tréhalose.
- pharmacologie : Acide benzoïque.
- Chromatographie gazeuse-spectrométrie de masse, Spectrométrie de masse MALDI, Électrophorèse bidimensionnelle sur gel.
English descriptors
- KwdEn :
- Alcohol Oxidoreductases (metabolism), Aldehyde Oxidoreductases (metabolism), Amino Acids (metabolism), Benzoic Acid (pharmacology), Carbohydrate Metabolism (drug effects), Citric Acid Cycle (drug effects), Cytochrome P-450 Enzyme System (metabolism), Down-Regulation (drug effects), Electrophoresis, Gel, Two-Dimensional (MeSH), Fungal Proteins (analysis), Fungal Proteins (metabolism), Gas Chromatography-Mass Spectrometry (MeSH), Glycolysis (drug effects), Heat-Shock Proteins (metabolism), NAD (metabolism), NADP (metabolism), Phanerochaete (drug effects), Phanerochaete (enzymology), Phanerochaete (metabolism), Proteome (analysis), Proteome (metabolism), Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization (MeSH), Trehalose (metabolism), Up-Regulation (drug effects).
- MESH :
- chemical , analysis : Fungal Proteins, Proteome.
- chemical , metabolism : Alcohol Oxidoreductases, Aldehyde Oxidoreductases, Amino Acids, Cytochrome P-450 Enzyme System, Fungal Proteins, Heat-Shock Proteins, NAD, NADP, Proteome, Trehalose.
- chemical , pharmacology : Benzoic Acid.
- drug effects : Carbohydrate Metabolism, Citric Acid Cycle, Down-Regulation, Glycolysis, Phanerochaete, Up-Regulation.
- enzymology : Phanerochaete.
- metabolism : Phanerochaete.
- Electrophoresis, Gel, Two-Dimensional, Gas Chromatography-Mass Spectrometry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization.
Abstract
Intracellular processes of the white-rot basidiomycete Phanerochaete chrysosporium involved in the metabolism of benzoic acid (BA) were investigated at the proteome and metabolome level. Up-regulation of aryl-alcohol dehydrogenase, arylaldehyde dehydrogenase, and cytochrome P450s was observed upon addition of exogenous BA, suggesting that these enzymes play key roles in its metabolism. Intracellular metabolic shifts from the short-cut TCA/glyoxylate bicycle system to the TCA cycle and an increased flux in the TCA cycle indicated activation of the heme biosynthetic pathway and the production of NAD(P)H. In addition, combined analyses of proteome and metabolome clearly indicated the role of trehalose as a storage disaccharide and that the mannitol cycle plays a role in an alternative energy-producing pathway.
DOI: 10.1021/pr700617s
PubMed: 18435559
Affiliations:
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Up-regulation of aryl-alcohol dehydrogenase, arylaldehyde dehydrogenase, and cytochrome P450s was observed upon addition of exogenous BA, suggesting that these enzymes play key roles in its metabolism. Intracellular metabolic shifts from the short-cut TCA/glyoxylate bicycle system to the TCA cycle and an increased flux in the TCA cycle indicated activation of the heme biosynthetic pathway and the production of NAD(P)H. In addition, combined analyses of proteome and metabolome clearly indicated the role of trehalose as a storage disaccharide and that the mannitol cycle plays a role in an alternative energy-producing pathway.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18435559</PMID><DateCompleted><Year>2008</Year><Month>08</Month><Day>21</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1535-3893</ISSN><JournalIssue CitedMedium="Print"><Volume>7</Volume><Issue>6</Issue><PubDate><Year>2008</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Journal of proteome research</Title><ISOAbbreviation>J Proteome Res</ISOAbbreviation></Journal><ArticleTitle>Proteomic and metabolomic analyses of the white-rot fungus Phanerochaete chrysosporium exposed to exogenous benzoic acid.</ArticleTitle><Pagination><MedlinePgn>2342-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/pr700617s</ELocationID><Abstract><AbstractText>Intracellular processes of the white-rot basidiomycete Phanerochaete chrysosporium involved in the metabolism of benzoic acid (BA) were investigated at the proteome and metabolome level. Up-regulation of aryl-alcohol dehydrogenase, arylaldehyde dehydrogenase, and cytochrome P450s was observed upon addition of exogenous BA, suggesting that these enzymes play key roles in its metabolism. Intracellular metabolic shifts from the short-cut TCA/glyoxylate bicycle system to the TCA cycle and an increased flux in the TCA cycle indicated activation of the heme biosynthetic pathway and the production of NAD(P)H. In addition, combined analyses of proteome and metabolome clearly indicated the role of trehalose as a storage disaccharide and that the mannitol cycle plays a role in an alternative energy-producing pathway.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Matsuzaki</LastName><ForeName>Fumiko</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Faculty of Agriculture, Bio-Architecture Center, Kyushu University, 6-10-1, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shimizu</LastName><ForeName>Motoyuki</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Wariishi</LastName><ForeName>Hiroyuki</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. 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UI="D009249">NADP</NameOfSubstance></Chemical><Chemical><RegistryNumber>8SKN0B0MIM</RegistryNumber><NameOfSubstance UI="D019817">Benzoic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>9035-51-2</RegistryNumber><NameOfSubstance UI="D003577">Cytochrome P-450 Enzyme System</NameOfSubstance></Chemical><Chemical><RegistryNumber>B8WCK70T7I</RegistryNumber><NameOfSubstance UI="D014199">Trehalose</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.1.-</RegistryNumber><NameOfSubstance UI="D000429">Alcohol Oxidoreductases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.1.1.90</RegistryNumber><NameOfSubstance UI="C055882">aryl-alcohol dehydrogenase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.2.-</RegistryNumber><NameOfSubstance UI="D000445">Aldehyde Oxidoreductases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.2.1.-</RegistryNumber><NameOfSubstance UI="C116588">aryl-aldehyde oxidoreductase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000429" MajorTopicYN="N">Alcohol Oxidoreductases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000445" MajorTopicYN="N">Aldehyde Oxidoreductases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000596" MajorTopicYN="N">Amino Acids</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019817" MajorTopicYN="N">Benzoic Acid</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050260" MajorTopicYN="N">Carbohydrate Metabolism</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug 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MajorTopicYN="N">Gas Chromatography-Mass Spectrometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006019" MajorTopicYN="N">Glycolysis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006360" MajorTopicYN="N">Heat-Shock Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009243" MajorTopicYN="N">NAD</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009249" MajorTopicYN="N">NADP</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020075" MajorTopicYN="N">Phanerochaete</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020543" MajorTopicYN="N">Proteome</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019032" MajorTopicYN="N">Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014199" MajorTopicYN="N">Trehalose</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>4</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>8</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>4</Month><Day>26</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18435559</ArticleId><ArticleId IdType="doi">10.1021/pr700617s</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country><region><li>Kyūshū</li><li>Préfecture de Fukuoka</li></region><settlement><li>Fukuoka</li></settlement><orgName><li>Université de Kyūshū</li></orgName></list><tree><noCountry><name sortKey="Shimizu, Motoyuki" sort="Shimizu, Motoyuki" uniqKey="Shimizu M" first="Motoyuki" last="Shimizu">Motoyuki Shimizu</name><name sortKey="Wariishi, Hiroyuki" sort="Wariishi, Hiroyuki" uniqKey="Wariishi H" first="Hiroyuki" last="Wariishi">Hiroyuki Wariishi</name></noCountry><country name="Japon"><region name="Kyūshū"><name sortKey="Matsuzaki, Fumiko" sort="Matsuzaki, Fumiko" uniqKey="Matsuzaki F" first="Fumiko" last="Matsuzaki">Fumiko Matsuzaki</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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